Serum Myeloperoxidase Levels Independently Predict Endothelial Dysfunction in Humans
نویسندگان
چکیده
منابع مشابه
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.
BACKGROUND In vitro and animal studies demonstrate that myeloperoxidase catalytically consumes nitric oxide as a substrate, limiting its bioavailability and function. We therefore hypothesized that circulating levels of myeloperoxidase would predict risk of endothelial dysfunction in human subjects. METHODS AND RESULTS Serum myeloperoxidase was measured by enzyme-linked immunoassay, and brach...
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ative role of UA in CV risk is primarily supported by in vitro study results demonstrating that exposure of cultured endothelial cells to UA induces NADPH oxidase activity and the production of reactive oxygen species.4 Conversely, the association between hyperuricemia and CV disease is only marginal or may be cofounded by other risk factors, such as hypertension, gout, and male sex. Likewise, ...
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BACKGROUND Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified lesions are considered more instable and rupture prone than calcified lesions. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes with plaque destabilisati...
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BACKGROUND Polymorphonuclear neutrophils (PMNs) have gained attention as critical mediators of acute coronary syndromes (ACS). Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and secreted during activation, possesses potent proinflammatory properties and may contribute directly to tissue injury. However, whether MPO also provides prognostic information in patients with ACS rem...
متن کاملSerum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity.
OBJECTIVE Interleukin (IL)-6 is a proinflammatory cytokine that is implicated in the pathogenesis of atherosclerosis and insulin resistance. Both endothelial dysfunction and insulin resistance are among the earliest abnormalities that can be detected in people at risk for cardiovascular events. We aimed to evaluate whether increased serum IL-6 concentrations associated with endothelial dysfunct...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000140262.20831.8f